ABSTRACT
Abstract Wolf's isotopic response designates the appearance of two subsequent unrelated dermatoses in the same anatomic location. We report the case of a 51-year-old man with a medical history of chronic lymphocytic leukemia without known extra-hematopoietic involvement. The patient developed a disseminated papulo-vesiculous eruption, diagnosed as varicella. Few days after recovering, an erythematous and violaceous papular dermatosis with histopathological examination compatible with leukemic infiltration appeared on the scars of previous herpetic lesions. Complete remission was obtained under systemic corticotherapy, without cutaneous recurrence or blastic transformation. Wolf's isotopic response is attributed to a localized immunologic imbalance following a certain stimulus. In this patient, herpetic infection acted as a local spur for inaugural cutaneous leukemic infiltration, with no impact on the prognosis for the underlying disease.
Subject(s)
Humans , Male , Middle Aged , Skin/pathology , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Chickenpox/pathology , Skin Diseases, Viral/pathology , Leukemic Infiltration/pathology , Immunohistochemistry , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Chickenpox/drug therapy , Treatment Outcome , Skin Diseases, Viral/drug therapy , Leukemic Infiltration/drug therapy , Dermis/pathology , Herpes Zoster/pathologyABSTRACT
Presentamos un paciente varón de 71 años con lesión tumoral en piel y antecedente de LLC. Los estudios histopatológicos y de inmunohistoquímica confirman el diagnóstico de Leucemia Cutis. Se realiza tratamiento con Clorambucilo y corticoides vía oral, remitiendo su enfermedad hematológica y cutánea. Actualmente luego de ocho meses del diagnóstico de LC, el paciente se encuentra libre de enfermedad.
We present a 71 year old male patient with previous records of Chronic Lymphocytic Leukaemia who presented with a tumoral skin lesion. Histological and immunohistochemical studies confirmed the Leukaemia Cutis diagnosis. The patient underwent treatment with clorambucile and systemic steroids with remision of both haemathological and skin manifestation. The patient is still under close clinical follow up and remission continues eight months so far.
Subject(s)
Humans , Male , Aged , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukemic Infiltration/pathology , Skin/pathology , Antineoplastic Agents, Alkylating/therapeutic use , Biopsy , Chlorambucil/therapeutic use , Immunohistochemistry , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Leukemic Infiltration/drug therapySubject(s)
Humans , Female , Aged , Leukemic Infiltration/diagnosis , Leukemia , Skin , Leukemic Infiltration/drug therapy , Leukemic Infiltration/radiotherapy , Leukemia , Skin NeoplasmsABSTRACT
A case of a 20-years-old black man from Salvador, Bahia with HTLV-I associated T cell lymphoma is presented. In spite of the absence of splenomegaly and leukemia, the patient had a marked cephalic tumoral infiltrationassociated with axillary tumors in a pattern not yet described in adult T cell lymphoma. Peripheral blood involvement was observed later on in the course of thedisease. The patient underwent chemotherapy but died seven monts after diagnosis